Skeletal Diseases in Cushing’s Syndrome: Osteoporosis versus Arthropathy
نویسندگان
چکیده
منابع مشابه
Skeletal diseases in Cushing's syndrome: osteoporosis versus arthropathy.
Structural and functional impairment of the skeletal system remains an important cause of morbidity and disability in patients with Cushing's syndrome (CS). Glucocorticoid (GC) excess inhibits bone formation and calcium absorption from the gut, increases bone resorption, and alters the secretion of gonadotropin and growth hormones, cytokines and growth factors influencing bone. Both overt and s...
متن کاملNeuropsychiatric Disorders in Cushings Syndrome
Glucocorticoids are crucial in the initiation and consolidation of the stress response. Patients with active Cushing’s syndrome (CS) are exposed to excessive endogenous glucocorticoid levels. In these patients, psychopathology is often being observed. The most common co-morbid disorder is major depression, but to a lesser extent mania and anxiety disorders have also been reported. A severe clin...
متن کاملNeuropsychiatric Disorders in Cushings Syndrome
Glucocorticoids are crucial in the initiation and consolidation of the stress response. Patients with active Cushing’s syndrome (CS) are exposed to excessive endogenous glucocorticoid levels. In these patients, psychopathology is often being observed. The most common co-morbid disorder is major depression, but to a lesser extent mania and anxiety disorders have also been reported. A severe clin...
متن کاملNeuropsychiatric Disorders in Cushings Syndrome
Glucocorticoids are crucial in the initiation and consolidation of the stress response. Patients with active Cushing’s syndrome (CS) are exposed to excessive endogenous glucocorticoid levels. In these patients, psychopathology is often being observed. The most common co-morbid disorder is major depression, but to a lesser extent mania and anxiety disorders have also been reported. A severe clin...
متن کاملPathophysiology of Diabetes Mellitus in Cushings Syndrome
Cushing’s syndrome is commonly complicated with an impairment of glucose metabolism, which is often clinically manifested as diabetes mellitus. The development of diabetes mellitus in Cushing’s syndrome is both a direct and indirect consequence of glucocorticoid excess. Indeed, glucocorticoid excess induces a stimulation of gluconeogenesis in the liver as well as an inhibition of insulin sensit...
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ژورنال
عنوان ژورنال: Neuroendocrinology
سال: 2010
ISSN: 1423-0194,0028-3835
DOI: 10.1159/000314298